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Promethazine with Codeine Oral Solution needs to be utilised with caution in sufferers with bone-marrow melancholy. Leukopenia and agranulocytosis have already been documented, commonly when promethazine has actually been Employed in Affiliation with other recognized marrow-harmful agents.
The phosphate salt of codeine occurs as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in h2o and a bit soluble in alcohol.
Someone caring for you need to look for unexpected emergency healthcare notice In case you have sluggish respiration with long pauses, blue colored lips, or If you're not easy to awaken.
While antihistamines are already located to produce fetal mortality in rodents, the pharmacological outcomes of histamine within the rodent don't parallel All those in guy. There isn't any ample and effectively-managed experiments of promethazine in Expecting Women of all ages.
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Discontinuation of the concomitantly made use of cytochrome P450 2D6 inhibitor may end in a decrease in codeine check here plasma focus and an increase in Lively metabolite morphine plasma concentration which could enhance or extend adverse reactions more info and could cause probably fatal respiratory depression.
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Promethazine with Codeine Syrup, a clear purple syrup with odor of grape menthol, has promethazine hydrochloride 6.
“This record will not involve all of the probable makes an attempt at contacting in the prescriptions to other different pharmacies which have determined it as fraud ahead of filling the prescription,” the document reads.
Excessively huge dosages of antihistamines, together with promethazine hydrochloride, in pediatric individuals may possibly cause sudden death (see OVERDOSAGE). Hallucinations and convulsions have transpired with therapeutic doses and overdoses of promethazine hydrochloride in pediatric individuals. In pediatric sufferers who're acutely sick click here affiliated with dehydration, there is a heightened susceptibility to dystonias with the usage of promethazine HCl.
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If you use this medication if you are pregnant, your toddler could grow to be depending on the drug. This may cause check here lifetime-threatening withdrawal signs in the child following it truly is born.